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Article Dans Une Revue Drug and Alcohol Dependence Année : 2018

Factors associated with perceived loss of libido in people who inject opioids: Results from a community-based survey in France

Facteurs associés avec la perte de libido perçue chez les personnes qui injectent des opiacés : Résultats d'une enquête communautaire en France

Virginie Laporte
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Résumé

BACKGROUND: Regular consumption of opioids exposes individuals to several side effects. One of these is a loss of libido, which has a negative impact on quality of life. We used a cross-sectional community-based survey of people who inject opioids to study factors associated with loss of libido, and more particularly the impact of the type of opioid injected. METHODS: This secondary study was conducted throughout France in 2015 and involved 514 people who inject opioids. Self-reported sociodemographic characteristics, drug consumption, injection-related data and loss of libido were collected using a brief questionnaire administered either through face-to-face interviews or online. Two different models were used to identify factors associated with loss of libido: simple logistic regression and a two-step Heckman model. RESULTS: Forty-three percent of the participants reported a loss of libido. The first model showed that filling in the questionnaire online (OR[95%CI] = 2.55[1.64;3.96]; p < 0.001), reporting that morphine sulfate (OR[95%CI] = 2.67[1.56;4.58]; p < 0.001) or methadone (OR[95%CI] = 2.50[1.13;5.56]; p = 0.030) was the opioid they injected most (versus buprenorphine), and reporting benzodiazepine use (OR[95%CI] = 1.62[1.07;2.44]; p = 0.033) were factors strongly associated with loss of libido. In the two-step, Heckman model which corrected for selection bias, along with these factors, reporting heroin as the opioid injected most was also strongly associated. CONCLUSION: Our findings showed that full-opioid agonists could have a negative impact on libido when injected regularly. Libido can improve quality of life and should be routinely discussed through counseling in prevention services with people who inject drugs.
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Dates et versions

hal-01873283 , version 1 (18-02-2019)

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Laélia Briand Madrid, Stéphane Morel, Khadim Ndiaye, Salim Mezaache, Daniela Rojas Castro, et al.. Factors associated with perceived loss of libido in people who inject opioids: Results from a community-based survey in France. Drug and Alcohol Dependence, 2018, 190, pp.121-127. ⟨10.1016/j.drugalcdep.2018.05.030⟩. ⟨hal-01873283⟩
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