Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa

Abstract : Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses , remains of great medical and public health concern. There is little doubt that the ancestral home of the species is Africa. This mosquito invaded the New World 400-500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of the New World invasion. Here, we use ~17,000 genome-wide single nucleotide polymor-phisms (SNPs) to characterize a heretofore undocumented complex picture of this mosquito across its ancestral range in Africa. We find signatures of human-assisted migrations, connectivity across long distances in sylvan populations, and of local ad-mixture between domestic and sylvan populations. Finally, through a phylogenetic analysis combined with the genetic structure analyses, we suggest West Africa and especially Angola as the source of the New World's invasion, a scenario that fits well with the historic record of 16th-century slave trade between Africa and Americas.
Complete list of metadatas

Cited literature [20 references]  Display  Hide  Download

Contributor : Philip Agnew <>
Submitted on : Wednesday, October 10, 2018 - 4:05:45 PM
Last modification on : Thursday, March 28, 2019 - 6:02:02 PM
Long-term archiving on : Friday, January 11, 2019 - 4:44:07 PM


Publisher files allowed on an open archive




Panayiota Kotsakiozi, Benjamin Evans, Andrea Gloria-Soria, Basile Kamgang, Martin Mayanja, et al.. Population structure of a vector of human diseases: Aedes aegypti in its ancestral range, Africa. Ecology and Evolution, Wiley Open Access, 2018, 8 (16), pp.7835-7848. ⟨10.1002/ece3.4278⟩. ⟨hal-01892439⟩



Record views


Files downloads