A. Zumla, J. Chakaya, and R. Centis, Tuberculosis treatment and management-an update on treatment regimens, trials, new drugs, and adjunct therapies, Lancet Resp Med, vol.3, pp.220-234, 2015.

M. A. Steele, D. Prez, and R. M. , The role of pyrazinamide in tuberculosis chemotherapy, Chest, vol.94, pp.845-850, 1988.

L. Heifets and P. Lindholm-levy, Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations, Am Rev Resp Dis, vol.145, pp.1223-1225, 1992.

, WHO. Global tuberculosis report, 2016.

, WHO treatment guidelines for drug-resistant tuberculosis: 2016 update

K. C. Chang, C. C. Leung, and W. W. Yew, Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis, Antimicrob Agents Chemother, vol.56, pp.5465-5475, 2012.

Y. Zhang, C. Chang, K. Leung, and C. C. , Z(S)-MDR-TB' versus 'Z(R)-MDR-TB': improving treatment of MDR-TB by identifying pyrazinamide susceptibility, Emerg Microb Infect, vol.1, p.5, 2012.

Y. Zhang, S. Permar, and Z. Sun, Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide, J Med Microbiol, vol.51, pp.42-49, 2002.

P. Chedore, L. Bertucci, and J. Wolfe, Potential for erroneous results indicating resistance when using the Bactec MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide, J Clin Microbiol, vol.48, pp.300-301, 2010.

S. Hoffner, K. Angeby, and E. Sturegard, Proficiency of drug susceptibility testing of Mycobacterium tuberculosis against pyrazinamide: the Swedish experience, Int J Tuberc Lung Dis, vol.17, pp.1486-1490, 2013.

M. Zignol, A. S. Dean, and N. Alikhanova, Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project, The Lancet infectious diseases, vol.16, pp.1185-1192, 2016.

K. Stoffels, V. Mathys, and M. Fauville-dufaux, Systematic analysis of pyrazinamideresistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis, Antimicrob Agents Chemother, vol.56, pp.5186-5193, 2012.

S. Petrella, N. Gelus-ziental, and A. Maudry, Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide, PLoS ONE, vol.6, p.15785, 2011.

Y. Zhang, W. Shi, W. Zhang, and D. Mitchison, Mechanisms of pyrazinamide action and resistance, Microbiol Spectr, vol.2, pp.1-12, 2013.

S. Zhang, J. Chen, and W. Shi, Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis, Emerg Microb Infect, vol.2, p.34, 2013.

W. Shi, X. Zhang, and X. Jiang, Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis, Science, vol.333, pp.1630-1632, 2011.

P. Miotto, A. M. Cabibbe, and S. Feuerriegel, Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study, mBio, vol.5, pp.1819-01814, 2014.

S. M. Ramirez-busby and F. Valafar, Systematic review of mutations in pyrazinamidase associated with pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates, Antimicrob Agents Chemother, vol.59, pp.5267-5277, 2015.

A. Scorpio, P. Lindholm-levy, and L. Heifets, Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis, Antimicrob Agents Chemother, vol.41, pp.540-543, 1997.

K. Hirano, M. Takahashi, and Y. Kazumi, Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis, Tuber Lung Dis, vol.78, pp.117-122, 1997.

S. Bhuju, S. Fonseca-lde, and A. G. Marsico, Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene, Infect Genet Evolut, vol.19, pp.1-6, 2013.

Y. Tan, Z. Hu, and T. Zhang, Role of pncA and rpsA gene sequencing in detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates from southern China, J Clin Microbiol, vol.52, pp.291-297, 2014.

D. Li, Y. Hu, and J. Werngren, Multicenter study of the emergence and genetic characteristics of pyrazinamide-resistant tuberculosis in China, Antimicrob Agents Chemother, vol.60, pp.5159-5166, 2016.

Y. Gu, X. Yu, and G. Jiang, Pyrazinamide resistance among multidrug-resistant tuberculosis clinical isolates in a national referral center of China and its correlations with pncA, rpsA, and panD gene mutations, Diagnos Microbiol Infect Dis, vol.84, pp.207-211, 2016.

, Vietnam national tuberculosis control programme N. Guidline for Management of Multidrug Resistance Tuberculosis, 2009.

N. V. Nhung, N. B. Hoa, and D. N. Sy, The fourth national anti-tuberculosis drug resistance survey in Viet Nam, Int J Tuberc Lung Dis, vol.19, pp.670-675, 2015.

, Guidelines for surveillance of drug resistance in tuberculosis, 2003.

V. A. Nguyen, H. Q. Nguyen, and T. T. Vu, Reduced turn-around time for Mycobacterium tuberculosis drug susceptibility testing with a proportional agar microplate assay, Clin Microbiol Infect, vol.21, pp.1084-1092, 2015.

J. Kamerbeek, L. Schouls, and A. Kolk, Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology, J Clin Microbiol, vol.35, pp.907-914, 1997.

C. Demay, B. Liens, and T. Burguiere, SITVITWEB-a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology, Infect Genet Evol, vol.12, pp.755-766, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-00691750

P. Supply, C. Allix, and S. Lesjean, Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis, J Clin Microbiol, vol.44, pp.4498-4510, 2006.

A. Sandgren, M. Strong, and P. Muthukrishnan, Tuberculosis drug resistance mutation database, PLoS Med, vol.6, p.2, 2009.

M. G. Whitfield, H. M. Soeters, and R. M. Warren, A global perspective on pyrazinamide resistance: systematic review and meta-analysis, PLoS One, vol.10, p.133869, 2015.

A. Aono, K. Chikamatsu, and H. Yamada, Association between pncA gene mutations, pyrazinamidase activity, and pyrazinamide susceptibility testing in Mycobacterium tuberculosis, Antimicrob Agents Chemother, vol.58, pp.4928-4930, 2014.

, Emerging Microbes & Infections

E. Martinez, N. Holmes, and P. Jelfs, Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis, J Antimicrob Chemotherapy, vol.70, pp.2511-2514, 2015.

N. V. Hung, H. Ando, and T. T. Thuy, Clonal expansion of Mycobacterium tuberculosis isolates and coexisting drug resistance in patients newly diagnosed with pulmonary tuberculosis in Hanoi, BMC Res Notes, vol.6, p.444, 2013.

I. Portugal, L. Barreiro, and J. Moniz-pereira, pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal, Antimicrob Agents Chemother, vol.48, pp.2736-2738, 2004.

P. Escalante, S. Ramaswamy, and H. Sanabria, Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru, Tuber Lung Dis, vol.79, pp.111-118, 1998.

M. Bamaga, D. J. Wright, and H. Zhang, Selection of in vitro mutants of pyrazinamide-resistant Mycobacterium tuberculosis, Int J Antimicrob Agents, vol.20, pp.275-281, 2002.

P. Jureen, J. Werngren, and J. C. Toro, Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis, Antimicrob Agents Chemother, vol.52, pp.1852-1854, 2008.

F. Rodrigues-vde, M. A. Telles, and M. O. Ribeiro, Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil, Antimicrob Agents Chemother, vol.49, pp.444-446, 2005.

A. Somoskovi, J. Dormandy, and L. M. Parsons, Sequencing of the pncA gene in members of the Mycobacterium tuberculosis complex has important diagnostic applications: Identification of a species-specific pncA mutation in 'Mycobacterium canettii' and the reliable and rapid predictor of pyrazinamide resistance, J Clin Microbiol, vol.45, pp.595-599, 2007.

Y. C. Chiu, S. F. Huang, and K. W. Yu, Characteristics of pncA mutations in multidrugresistant tuberculosis in Taiwan, BMC Infect Dis, vol.11, p.240, 2011.

Q. Xia, L. L. Zhao, and F. Li, Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Zhejiang, China, Antimicrob Agents Chemother, vol.59, pp.1690-1695, 2015.

F. Doustdar, A. D. Khosravi, and P. Farnia, Mycobacterium tuberculosis genotypic diversity in pyrazinamide-resistant isolates of Iran, Microb Drug Resist, vol.15, pp.251-256, 2009.

V. A. Nguyen, A. L. Banuls, and T. H. Tran, Mycobacterium tuberculosis lineages and antituberculosis drug resistance in reference hospitals across Viet Nam, BMC Microbiol, vol.16, p.167, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02003072

A. L. Hertog, S. Sengstake, and R. M. Anthony, Pyrazinamide resistance in Mycobacterium tuberculosis fails to bite?, Pathogens Dis, vol.73, p.37, 2015.

B. Muller, V. N. Chihota, and M. Pillay, Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa, PLoS One, vol.8, p.70919, 2013.

K. A. Cohen, T. Abeel, M. Mcguire, and A. , Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal, PLoS Med, vol.12, p.1001880, 2015.