, gambiense secretome down regulated cytokines production by LPS-activated Mo-DCs
Immune evasion strategies of Trypanosoma brucei within the mammalian host: progression to pathogenicity. Front Immunol, vol.7, p.233, 2016. ,
Innate immunomodulation to trypanosomatid parasite infections, Clin Microbiol Infect, vol.17, issue.3, pp.67-75, 2011. ,
The Trypanosoma brucei gambiense secretome impairs lipopolysaccharide-induced maturation, cytokine production, and allostimulatory capacity of dendritic cells, Infect. Immun, pp.3300-3308, 201381. ,
CpG oligodeoxynucleotide treatment enhances innate resistance and acquired immunity to African trypanosomes, Infect. Immun, 200775. ,
Dendritic cells and the control of immunity, Nature, vol.392, pp.245-252, 1998. ,
mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function, Trends Immunol, vol.7, 2016. ,
Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses, Eur. J. Immunol, vol.41, pp.3479-3494, 2011. ,
DOI : 10.1002/eji.201141631
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201141631
Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling, PLoS Pathog, vol.6, 2010. ,
DOI : 10.1371/journal.ppat.1001045
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001045&type=printable
Processing and presentation of variant surface glycoprotein molecules to T cells in African trypanosomiasis, J. Immunol, vol.183, pp.3344-3355, 2009. ,
Trypanosome hydrolase and the blood-brain barrier, Trends Parasitol, vol.18, pp.17-19, 2002. ,
Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics. Microbes Infect, vol.10, pp.79-86, 2008. ,
Exocytosis and protein secretion in Trypanosoma, BMC Microbiology, vol.10, p.20, 2010. ,
DOI : 10.1186/1471-2180-10-20
URL : https://bmcmicrobiol.biomedcentral.com/track/pdf/10.1186/1471-2180-10-20
Excreted/secreted proteins from trypanosome procyclic strains, J Biomed Biotechnol, p.212817, 2010. ,
Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose, Exp. Parasitol, vol.28, pp.521-534, 1970. ,
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha, J Exp Med, vol.179, pp.1109-1127, 1994. ,
Signals required for differentiating dendritic cells from human monocytes in vitro, Adv Exp Med Biol, vol.329, pp.275-80, 1993. ,
Trypanosoma brucei brucei infection impairs MHC Class II antigen presentation capacity of macrophages, Parasite Immunol, vol.22, pp.361-370, 2000. ,
DOI : 10.1046/j.1365-3024.2000.00314.x
URL : https://biblio.ugent.be/publication/8615025/file/8615027.pdf
How the African trypanosomes evade host immune killing, Parasite Immunol, vol.33, pp.430-437, 2011. ,
Trypanosoma congolense infections: MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function, Parasite Immunol, vol.29, pp.107-118, 2007. ,
The transcriptomic analytical level determines the human monocyte-derived macrophage response toward either the infectious agent or the host, Infect Genet Evol, vol.45, pp.426-433, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01594519
Processing and presentation of variant surface glycoprotein molecules to T cells in African trypanosomiasis, J Immunol, vol.183, pp.3344-3355, 2009. ,
TRAF6 is a critical factor for dendritic cell maturation and development, Immunity, vol.19, pp.353-363, 2003. ,
DOI : 10.1016/s1074-7613(03)00230-9
URL : https://doi.org/10.1016/s1074-7613(03)00230-9
Trypanosoma cruzi infects human dendritic cells and prevents their maturation: inhibition of cytokines, HLA-DR, and costimulatory molecules, Infect. Immun, vol.67, pp.4033-4040, 1999. ,
Leishmania amazonensis impairs DC function by inhibiting CD40 expression via A2B adenosine receptor activation, Eur. J. Immunol, vol.42, pp.1203-1215, 2012. ,
DOI : 10.1002/eji.201141926
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201141926
Activated macrophages destroy intracellular Leishmania major amastigotes by an L-argininedependentkilling mechanism, J. Immunol, vol.144, pp.278-283, 1990. ,
Macrophage cytostatic effect on, 1991. ,
, Trypanosoma musculi involves an L-arginine-dependent mechanism, J. Immunol, vol.146, pp.4338-4343
Nitric oxide synthase in innate and adaptive immunity: an update, 2015. ,
DOI : 10.1016/j.it.2015.01.003
, Trends Immunol, vol.36, pp.161-178
LArginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis, Infect. Immun, vol.68, pp.4653-4657, 2000. ,
DOI : 10.1128/iai.68.8.4653-4657.2000
URL : https://iai.asm.org/content/68/8/4653.full.pdf
Alternative versus classical macrophage activation during experimental African trypanosomosis, J. Leukoc. Biol, vol.69, pp.387-396, 2001. ,
,
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation, J. Leukoc. Biol, vol.77, pp.321-327, 2005. ,
The trypanothione system and its implications in the therapy of trypanosomatid diseases, Int. J. Med. Microbiol, vol.302, pp.216-220, 2012. ,
, , 2013.
, Macrophage plasticity and polarization in tissue repair and remodelling, J. Pathol, vol.229, pp.176-185
,
Serum arginase, a biomarker of treatment efficacy in human African trypanosomiasis, J. Clin. Microbiol, vol.51, pp.435-2379, 2013. ,
,
Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect, J. Immunol, vol.172, pp.6298-6303, 2004. ,
,
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity, 2013. ,
, PloS Pathog, vol.9, issue.10, p.1003731
Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster, Biochemistry, vol.54, pp.458-71, 2015. ,
The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T cell deprivation, Clin. Exp. Immunol, vol.16, pp.279-293, 1974. ,
Macrophage functions during Trypanosoma musculi infection in mice, Infect. Immun, vol.34, pp.378-381, 1981. ,
Identification of antibody classes and Fc receptors responsible for phagocytosis of Trypanosoma musculi by mouse macrophages, Infect. Immun, vol.53, pp.600-605, 1986. ,
Immune and nonimmune regulation of the population of Trypanosoma musculi in infected host mice, Infect. Immun, vol.58, pp.1757-1762, 1990. ,
Verbreitung wirt-parasit-beziehungen und vermehrung sizilianischer Stämme von Trypanosoma (Herpetosoma) duttoni Thiroux.1905 (Protozoa, Trypanosomatidae), Z. Parasitenkd, vol.32, pp.297-315, 1969. ,
Separation of trypanosomes from the blood of infected rats and mice by anion-exchangers, Nature, vol.218, issue.5148, pp.1273-1274, 1968. ,
Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics, Microbes Infect, vol.10, pp.79-86, 2008. ,
Cleavage of structural proteins during the assembly of head of bacteriophage T4, Nature, vol.227, pp.680-685, 1970. ,
,
Identification of a tryptophan-like epitope borne by the variable surface glycoprotein (VSG) of African trypanosomes, Exp. Parasitol, vol.115, pp.173-180, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00163391
Identification and characterization of new Leishmania promastigote surface antigens, LaPSA-38S and LiPSA-50S, as major immunodominant excreted/secreted components of L. amazonensis and L. infantum, Infect. Genet. Evol, vol.24, pp.1-14, 2014. ,
In vitro growth of Trypanosoma musculi in cell free medium conditioned by rodent macrophages and mercaptoethanol, Int. J. Parasitol, vol.10, pp.137-142, 1980. ,
In vitro growth of Trypanosoma musculi: requirements of cells and serum-free culture medium, Int. J. Parasitol, vol.16, pp.387-390, 1985. ,
Determination of arginase activity in macrophages: a micromethod, J. Immunol. Methods, vol.174, pp.231-235, 1994. ,
MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0, Mol. Biol. Evol, vol.30, pp.2725-2729, 2013. ,
Metabolism and functions of trypanothione in the Kinetoplastida, Annu. Rev. Microbiol, vol.46, pp.695-729, 1992. ,
,
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial, Lancet, vol.374, issue.9683, pp.56-64, 2009. ,
An evolutionary perspective on C-type lectins in infection and immunity, Ann. N. Y. Acad. Sci, vol.1253, pp.149-58, 2012. ,
Adaptive immunity to fungi, Annu. Rev. Immunol, vol.30, pp.115-148, 2012. ,
Immune escape through Ctype lectins on dendritic cells, Trends Immunol, vol.23, pp.480-485, 2002. ,
,
The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum, Immunity, vol.38, pp.1038-1049, 2013. ,
The mannose receptor, J. Leukoc. Biol, vol.92, pp.1177-1186, 2012. ,
The increase in mannose receptor recycling favors arginase induction and Trypanosoma cruzi survival in macrophages, Int. J. Biol. Sci, vol.7, pp.1257-1272, 2011. ,
,
Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial, Vaccine, vol.25, pp.4223-4234, 2007. ,
,
, A cross-sectional sero-epidemiological study of canine leishmaniasis in Greek mainland, Acta Trop, vol.122, pp.291-295
, Effective humoral and cellular immunoprotective responses in, 2009.
, Li ESAp-MDP vaccinated protected dogs, Vet. Immunol. Immunopathol, vol.128, pp.71-78
The molecular evolution of trypanosomes, 1999. ,
, Parasitol. Today, vol.15, pp.432-439
,
Phylogeny, taxonomy and grouping of Trypanosoma rangeli isolates from man, triatomines and sylvatic mammals from widespread geographical origin based on SSU and ITS ribosomal sequences, Parasitology, vol.129, pp.549-561, 2004. ,
Redirection of the immune response to the functional catalytic domain of the cystein proteinase cruzipain improves protective immunity against Trypanosoma cruzi infection, J. Infect. Dis, vol.202, pp.136-144, 2010. ,
Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi, Subcell Biochem, vol.47, pp.140-154, 2008. ,
Vaccination against trypanosomiasis: can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?, Hum. Vaccin, vol.7, pp.1225-1233, 2011. ,
A recombinant multi-antigen vaccine formulation containing Babesia bovis merozoite surface antigens MSA-2a1, MSA-2b and MSA-2c elicits invasion-inhibitory antibodies 540 and IFN? producing cells, Parasit. Vectors, vol.9, p.577, 2016. ,
The surface coat of procyclic Trypanosoma brucei: programmated expression and proteolytic cleavage of procyclin in the tsetse fly, Proc Natl Acad Sci U S A, vol.98, pp.1513-1521, 2001. ,
Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases, Antimicrob Agents Chemother, vol.43, pp.2910-2914, 1999. ,
Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter, Antimicrob Agents Chemother, vol.55, pp.5113-5134, 2011. ,
Nifurtimoxeflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Medecins Sans Frontieres experience in the Democratic Republic of the Congo, Clin Infect Dis, vol.56, pp.195-203, 2013. ,
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome, Genome Research, vol.21, pp.915-939, 2011. ,
Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream, Mol. Microbiol, vol.51, pp.1577-1588, 2004. ,
Distinct Toll-like receptor signals regulate cerebral parasite load and interferon ?/? and tumor necrosis factor ?-dependent T-cell infiltration in the brains of Trypanosoma brucei-infected mice, J Infect Dis, vol.2, pp.320-352, 2012205. ,
The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis, Mem Inst Oswaldo Cruz, vol.107, pp.416-419, 2012. ,
Evaluation of a 12-color flow cytometry panel to study lymphocyte, monocyte, and dendritic cell subsets in humans, Cytometry A, vol.77, pp.410-419, 2010. ,
Polyamine metabolism: a potential therapeutic target in trypanosomes, Science, vol.210, pp.332-334, 1980. ,
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease, Antimicrob Agents Chemother, vol.58, pp.4362-4370, 2014. ,
Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Medecins Sans Frontières programmes, Trans R Soc Trop Med Hyg, vol.103, pp.280-290, 2009. ,
Dendritic cells and the control of immunity, Nature, vol.392, pp.245-252, 1998. ,
Biochemical aspects of ergosterol biosynthesis inhibition in Emerging Targets in Antibacterial and Antifungal Chemotherapy, pp.410-436, 1992. ,
A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates, Mol Biochem Parasitol, vol.86, pp.95-104, 1997. ,
Paraflagellar rod is vital for trypanosome motility, Nature, vol.391, p.548, 1998. ,
A receptor-like flagellar pocket glycoprotein specific to Trypanosoma brucei gambiense, Mol. Biochem. Parasitol, vol.113, pp.127-138, 2001. ,
L'évolution créatrice. 1907. Collection Quadrige, PUF ,
Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase, Annual Review of Microbiology, vol.49, pp.607-639, 1995. ,
Tolerance to Trypanosomatids: A Threat, or a Key for Disease Elimination?, Trends Parasitol, vol.32, pp.157-68, 2016. ,
, Science, vol.309, pp.416-438, 2005.
Amiodarone has intrinsic antiTrypanosoma cruzi activity and acts synergistically with posaconazole, Journal of Medicinal Chemistry, vol.49, pp.892-899, 2006. ,
Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellites markers, Mol Biochem Parasitol, vol.105, pp.185-201, 2000. ,
Induction and regulation of Trypanosoma brucei VSG-specific antiboby response, Parasitology, vol.14, pp.2041-2049, 2010. ,
The intraflagellar transport dynein complex of trypanosomes is made of a heterodimer of dynein heavy chains and of light and intermediate chains of distinct functions, Mol Biol Cell, vol.25, pp.2620-2653, 2014. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01301215
Biogenesis of the trypanosome endo-exocytotic organelle is cytoskeleton mediated, PLoS Biol, vol.6, p.105, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00318588
Antigenic variation and allelic exclusion, Cell, vol.109, pp.5-8, 2002. ,
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase, Biochem Biophys Res Commun, vol.203, pp.1614-1635, 1994. ,
URL : https://hal.archives-ouvertes.fr/hal-00315248
Lysosomal membrane permeabilization in cell death, Oncogene, vol.27, pp.6434-6451, 2008. ,
Effects of squalene synthase inhibitors on the growth and ultrastructure of Trypanosoma cruzi, International Journal of Antimicrobial Agents, vol.24, pp.72-78, 2004. ,
Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways, Molecular Microbiology, vol.96, pp.917-926, 2015. ,
Identification of Trypanosoma brucei gambiense by PCR amplification of variant surface glycoprotein genes, Acta Trop (Basel), vol.53, pp.107-126, 1993. ,
Flow cytometry: principles and clinical applications in hematology, Clin Chem, vol.46, pp.1221-1230, 2000. ,
A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents, Proc Natl Acad Sci U S A, vol.100, pp.15149-53, 2003. ,
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense a randomised trial, Lancet, vol.355, pp.1419-1425, 2000. ,
Chemotherapy against human African trypanosomiasis: is there a road to success?, Parasitology, vol.137, pp.1987-1994, 2010. ,
Orchestrating lymphocyte polarity in cognate Immune Cell-Cell Interactions, Int Rev Cell Mol Biol, vol.327, pp.195-261, 2016. ,
Ciliary and flagellar apparatuses and their associated structures, Biol Cell, vol.63, p.115, 1988. ,
The Dermis as a Delivery Site of Trypanosoma brucei for tsetse flies, PLoS Pathog, vol.12, p.1005744, 2016. ,
Quinuclidine derivatives as potential antiparasitics, Antimicrobial Agents and Chemotherapy, vol.51, pp.4049-4061, 2007. ,
Inhibition of lipopolysaccharide induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine proteases and the NF?B signaling pathway, J. Immunol, vol.173, pp.3297-3304, 2004. ,
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite, J. Immunol, vol.167, pp.416-423, 2001. ,
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88, J. Immunol, vol.172, pp.1711-1718, 2004. ,
Human arginase II: crystal structure and physiological role in male and female sexual arousal, Biochemistry, vol.42, pp.8445-51, 2003. ,
The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense, PLoS Pathog, vol.9, p.1003686, 2013. ,
The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes, Elife, vol.5, 2016. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01371190
Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis, Clin Infect Dis, vol.41, pp.748-751, 2005. ,
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole, PLoS Negl Trop Dis, vol.4, p.651, 2010. ,
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition, Febs Letters, vol.588, pp.3878-3885, 2014. ,
Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in stat1 phosphorylation in African trypanosomiasis, Journal of immunology, vol.171, pp.1466-1472, 2003. ,
Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite, Proc Natl Acad Sci U S A, vol.85, pp.6753-6757, 1988. ,
Arginase-boronic acid complex highlights a physiological role in erectile function, Nat Struct Biol, vol.6, pp.1043-1050, 1999. ,
Processing and presentation of variant surface glycoprotein molecules to T cells in African trypanosomiasis, J. Immunol, vol.183, pp.3344-3355, 2009. ,
A protein kinase antigenically related to pp60v-src possibly involved in yeast cell cycle control: positive in vivo regulation by sterol, Proc Natl Acad Sci USA, vol.84, pp.4012-4016, 1987. ,
A single amino acid substitution in the group 1 Trypanosoma brucei gambiense haptoglobinhaemoglobin receptor abolishes TLF-1 binding, PLoS Pathog, p.1003317, 2013. ,
Dendritic cell-mediated T cell polarization, Springer Semin Immunopathol, vol.3, pp.289-307, 200526. ,
Uptake of pentamidine in Trypanosoma brucei brucei is mediated by the P2 adenosine transporter and at least one novel, unrelated transporter, Acta Trop, vol.80, pp.245-250, 2001. ,
In vitro activity of the antifungal azoles itraconazole and posaconazole against Leishmania amazonensis, PLoS One, vol.8, p.83247, 2013. ,
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity, PLoS Pathog, vol.9, p.1003731, 2013. ,
GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida, Febs letters, vol.491, pp.148-53, 2001. ,
Sterol biosynthesis pathway as target for antitrypanosomatid drugs, Interdiscip. Perspect. Infect. Dis, pp.1-19, 2009. ,
Restriction of the alternative pathway of human complement by intact Trypanosoma brucei sub sp. gambiense, Infect Immun, vol.52, pp.223-232, 1986. ,
Ca 2+ is essential cofactor of trypanocidal activity of normal human serum, Nature, vol.282, pp.613-615, 1979. ,
Indoleamine 2,3-dioxygenase (IDO) induced by Leishmania infection of human dendritic cells, Parasite Immunol, vol.34, pp.464-72, 2012. ,
Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes, J. Biol. Chem, vol.276, pp.30254-30260, 2001. ,
The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88-dependent, J Immunol, vol.175, pp.2501-2509, 2005. ,
Mouse Strain Susceptibility to Trypanosome Infection: An Arginase-Dependent Effect, J Immunol, vol.172, pp.6298-303, 2004. ,
Note on a Trypanosoma occurring in the blood of man, British Medical Journal, vol.2177, pp.881-884, 1902. ,
Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway, Annu Rev Biochem, vol.68, pp.157-185, 1999. ,
Comparative genomics of trypanosomatid parasitic protozoa, Science, vol.309, pp.404-409, 2005. ,
The trypanosome flagellar pocket, Nat Rev Microbiol, vol.7, pp.775-786, 2009. ,
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, vol.391, pp.806-817, 1998. ,
RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon-?primed macrophages, Eur. J. Immunol, vol.36, pp.411-420, 2006. ,
The discovery of the human Trypanosoma, British Medical Journal, vol.2187, p.1741, 1902. ,
The increase in mannose receptor recycling favors arginase induction and Trypanosoma cruzi survival in macrophages, Int J Biol Sci, vol.7, pp.1257-72, 2011. ,
The Trypanosoma brucei gambiense secretome impairs Lipopolysaccharide-induced maturation, cytokine production, and allostimulatory capacity of dendritic cells, Infection and Immunity, vol.8, pp.3300-3308, 2013. ,
Assembly and localization of Tolllike receptor signalling complexes, Nat Rev Immunol, vol.14, pp.546-58, 2014. ,
Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism, Nat Rev Immunol, vol.12, issue.6, pp.895-906, 2006. ,
C-type lectin receptors in the control of T helper cell differentiation, Nat Rev Immunol, vol.7, pp.433-481, 201616. ,
Exocytosis and protein secretion in Trypanosoma, BMC Microbiology, vol.10, p.20, 2010. ,
Will the real Trypanosoma gambiense please stand up, Parasitol Today, vol.2, pp.255-262, 1986. ,
Conserved sequence of the TgsGP gene in Group 1 Trypanosoma brucei gambiense, Infect. Genet. Evol, vol.10, pp.453-458, 2010. ,
Murine Models for Trypanosoma brucei gambiense disease progression-from silent to chronic infections and early brain tropism, PLoS Negl Trop Dis ,
URL : https://hal.archives-ouvertes.fr/hal-00426327
The immunological synapse: a molecular machine controlling T cell activation, Science, vol.285, p.221, 1999. ,
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action, Antimicrobial Agents and Chemotherapy, vol.50, pp.2595-2601, 2006. ,
L-Arginine availability modulates local nitric oxide production and parasite killing in experimental trypanosomiasis, Infect Immun, vol.68, pp.4653-4660, 2000. ,
Protein sensors for membrane sterols, Cell, vol.124, pp.35-46, 2006. ,
Identification of total and differentially expressed excreted-secreted proteins from Trypanosoma congolense strains exhibiting different virulence and pathogenicity, Int. J. Parasitol, vol.39, pp.1137-1150, 2009. ,
Tryptophan catabolism in nonobese diabetic mice, Adv Exp Med Biol, vol.527, pp.47-54, 2003. ,
Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization, J Immunol, vol.128, pp.2779-87, 1982. ,
African Trypanosomiasis: Naturally Occurring Regulatory T Cells Favor Trypanotolerance by Limiting Pathology Associated with Sustained Type 1, Inflammation J Immunol, vol.179, pp.2748-2757, 2007. ,
The cytoskeleton of trypanosomatid parasites, Annu Rev Microbiol, vol.53, pp.629-655, 1999. ,
Mechanism of resistance of African trypanosomes to cytotoxic human HDL, Nature, vol.385, pp.823-826, 1997. ,
Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation, PLoS Pathog, vol.9, p.1003502, 2013. ,
Induction of the trypanosome lymphocytetriggering factor (TLTF) and neutralizing antibodies to the TLTF in experimental african trypanosomiasis, Immunology, vol.96, pp.606-617, 1999. ,
Interferon-gamma induces secretion of trypanosome lymphocyte triggering factor via tyrosine protein kinases, Parasitology, vol.120, pp.281-288, 2000. ,
Cell cycle regulation in Trypanosoma brucei, Mol Biochem Parasitol, vol.153, pp.1-8, 2007. ,
Cytokinesis in trypanosomatids, Current Opinion in Microbiology, vol.10, pp.520-527, 2007. ,
Complexes of Trypanosoma cruzi Sterol 14?-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: structural basis for pathogen selectivity, J Biol Chem, vol.288, pp.31602-31615, 2013. ,
Dendritic cells: unique leukocyte populations which control the primary immune response, Blood, vol.90, pp.3245-3287, 1997. ,
Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth, Journal of Lipid Research, vol.56, pp.331-341, 2015. ,
The differentiation of Trypanosoma rhodesiense from T. brucei by means of human serum, Trans R Soc Trop Med Hyg, vol.67, pp.517-527, 1973. ,
Direct Blood Dry LAMP: A Rapid, Stable, and Easy Diagnostic Tool for Human African Trypanosomiasis, PLoS Negl Trop Dis, vol.9, p.3578, 2015. ,
Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens, Immunol Rev, vol.199, pp.9-26, 2004. ,
Telomeric expression sites are highly conserved in Trypanosoma brucei, Plos One, vol.3, p.3527, 2008. ,
The identification of Trypanosoma brucei subspecies using repetitive DNA sequences, Mol Biochem Parasitol, vol.39, pp.213-238, 1990. ,
The trypanosomes of mammals. A zoological monograph, Blackwell Scientific Publications, 1972. ,
Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics, Microbes Infect, vol.10, pp.79-86, 2008. ,
The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes, Chromosome Res, vol.13, pp.525-533, 2005. ,
Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure, Emerg Infect Dis, vol.15, pp.1068-1076, 2009. ,
Trypanosome-induced Interferon-? production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections, Microbes Infect, vol.18, pp.436-476, 2016. ,
Growth inhibition and ultrastructural alterations induced by ?24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms, BMC Microbiology, vol.9, p.74, 2009. ,
Untreated human infections by Trypanosoma brucei gambiense are not 100% fatal, PLoS Negl Trop Dis, vol.6, p.1691, 2012. ,
?24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme, Molecular and Biochemical Parasitology, vol.160, pp.52-59, 2008. ,
Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome, PLoS Negl Trop Dis, vol.9, p.4299, 2015. ,
Genetic heterogeneity in the Trypanosoma brucei gambiense genome analysed by random amplification of polymorphic DNA, Parasitol Res, vol.82, pp.535-576, 1996. ,
Dendritic-cell control of pathogen-driven T-cell polarization, Nat. Rev. Immunol, vol.3, pp.984-993, 2003. ,
DOI : 10.1038/nri1246
The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness, Allergy Asthma Clin Immunol, vol.12, p.4, 2016. ,
TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA, PLoS Negl Trop Dis, vol.8, p.3308, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01342968
Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor, PNAS, vol.107, pp.16137-16141, 2010. ,
Trypanosomiasis in a woman from Cameroon mimicking systemic lupus erythematosus, Dtsch. Med. Wochenschr, vol.129, pp.1315-1317, 2004. ,
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity, J. Biol. Chem, vol.280, pp.8606-8616, 2005. ,
Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters, Mol Biochem Parasitol, vol.111, pp.67-76, 2000. ,
Motility and more: the flagellum of Trypanosoma brucei, Nat Rev Microbiol, vol.12, pp.505-523, 2014. ,
Ultrastructural alterations induced by two ergosterol biosynthesis inhibitors, ketoconazole and terbinafine, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi, Antimicrobial Agents and Chemotherapy, vol.34, pp.2097-2105, 1990. ,
La classification phylogénétique du vivant, 2006. ,
The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum, Immunity, vol.38, pp.1038-1087, 201323. ,
CYP51 from Trypanosoma brucei is obtusifoliol-specific, Biochemistry, vol.43, pp.10789-10799, 2004. ,
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth, Chem Biol, vol.14, pp.1283-1293, 2007. ,
DOI : 10.1016/j.chembiol.2007.10.011
URL : https://doi.org/10.1016/j.chembiol.2007.10.011
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms, Biochim Biophys Acta, vol.1770, pp.467-477, 2007. ,
DOI : 10.1016/j.bbagen.2006.07.018
URL : http://europepmc.org/articles/pmc2324071?pdf=render
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections, J Biol Chem, vol.285, pp.1773-1780, 2010. ,
Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis, Curr Top Med Chem, vol.11, pp.2060-2071, 2011. ,
VFV as a New Effective CYP51 structure-derived drug candidate for Chagas disease and visceral leishmaniasis, The Journal of Infectious Diseases, vol.212, pp.1439-1487, 2015. ,
DOI : 10.1093/infdis/jiv228
URL : http://europepmc.org/articles/pmc4601915?pdf=render
Changes in susceptibility to posaconazole in clinical isolates of Candida albicans, J Antimicrob Chemother, vol.53, pp.74-80, 2004. ,
Krüppel-like factor 4 regulates macrophage polarization, J Clin Invest, vol.121, pp.2736-2785, 2011. ,
DOI : 10.1172/jci45444
URL : http://www.jci.org/articles/view/45444/files/pdf
PDL1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal, J Clin Cell Immunol, vol.30, p.12, 2012. ,
Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes, Molecular and Biochemical Parasitology, vol.104, pp.81-91, 1999. ,
DOI : 10.1016/s0166-6851(99)00129-2
Trypanosome hydrolase and the blood-brain barrier, Trends Parasitol, vol.18, pp.17-19, 2002. ,
Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa, Bioorganic and Medicinal Chemistry, vol.13, pp.3519-3529, 2005. ,
,
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets, J Exp Med, vol.213, pp.1589-608, 2016. ,
Azasterols as inhibitors of sterol 24methyltransferase in Leishmania species and Trypanosoma cruzi, Journal of Medicinal Chemistry, vol.46, pp.4714-4727, 2003. ,
Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections, Infect. Immun, vol.67, pp.3128-3132, 1999. ,
Interferon-gamma and nitric oxide in collaboration with antibodies are key protective host immune factors during trypanosome Tc13 infections, J Infect Dis, vol.193, pp.1575-1583, 2006. ,
Sleeping sickness, Clin Microbiol Infect, vol.17, pp.986-995, 2011. ,
Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase, Antimicrob Agents Chemother, vol.47, pp.577-581, 2003. ,
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure, Genome Res, vol.17, pp.1344-1352, 2007. ,
Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase, Glycobiology, vol.20, pp.1619-1649, 2010. ,
The developmental cell biology of Trypanosoma brucei, Journal of Cell Science, vol.118, pp.283-290, 2005. ,
IDO expression by dendritic cells: tolerance and tryptophan catabolism, Nat Rev Immunol, vol.4, pp.762-74, 2004. ,
DOI : 10.1038/nri1457
Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alphademethylase, PLoS Negl Trop Dis, vol.9, p.3588, 2015. ,
Coordination of cell cycle and cytokinesis in Trypanosoma brucei, Curr Opin Microbiol, vol.6, pp.600-607, 2003. ,
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1? and glycolysis in macrophages as a mechanism of innate immune evasion, Proc Natl Acad Sci U S A, vol.113, pp.7778-7787, 2016. ,
Matthews KR Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act, Nature reviews Microbiology, vol.10, pp.431-438, 2012. ,
Excreted/secreted proteins from trypanosome procyclic strains; J of biomedicine and biotechnology, p.212817, 2010. ,
Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoininduced failure of dendritic cell function, J. Biol, vol.5, p.5, 2006. ,
Lanosterol 14alpha-demethylase. Similarity of the enzyme system from yeast and rat liver, Steroids, vol.6, pp.821-829, 1976. ,
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts, Antimicrob Agents Chemother, vol.44, pp.150-155, 2000. ,
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model, J. Exp. Med, vol.205, pp.1721-1728, 2008. ,
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies, J Biol Chem, vol.278, pp.17075-83, 2003. ,
Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity, Cell. Microbiol, vol.11, pp.1724-1734, 2009. ,
DOI : 10.1111/j.1462-5822.2009.01383.x
URL : http://eprints.gla.ac.uk/8339/1/8339.pdf
T-cell and mast cell lines respond to B-cell stimulatory factor 1, Proc Natl Acad Sci, vol.83, pp.5654-5662, 1986. ,
DOI : 10.1073/pnas.83.15.5654
URL : http://www.pnas.org/content/83/15/5654.full.pdf
Speciesspecificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4), J Immunol, vol.138, pp.1813-1819, 1987. ,
RNA interference for analysis of gene function in trypanosomatids, Curr Opin Microbiol, vol.7, pp.362-368, 2004. ,
How to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness, J Infect Dis, vol.201, pp.453-463, 2010. ,
Arginase: an emerging key player in the mammalian immune system, British Journal of Pharmacology, vol.158, pp.638-651, 2009. ,
Trypanosoma brucei brucei infection impairs MHC Class II antigen presentation capacity of macrophages, Parasite Immunol, vol.22, pp.361-370, 2000. ,
Effects of exogenous transforming factor b on Trypanosoma congolense infection in mice, Infect Immun, vol.75, pp.1878-1885, 2007. ,
Quantitative differences in immune responses in mouse strains that differ in their susceptibility to Trypanosoma brucei brucei infection, J Vet Med, vol.71, pp.951-956, 2009. ,
How the African trypanosomes evade host immune killing, Parasite Immunology, vol.33, pp.430-437, 2011. ,
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans, Plant Cell, vol.2, pp.279-289, 1990. ,
pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei, Nature, vol.414, pp.759-763, 2001. ,
Nuclear architecture underlying gene expression in Trypanosoma brucei, Trends Microbiol, vol.15, pp.263-270, 2007. ,
DOI : 10.1016/j.tim.2007.04.004
, Biochemistry of Steroids and Other Isoprenoids, 1977.
Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms, Biochem J, vol.443, pp.267-277, 2012. ,
Double-stranded RNA induces mRNA degradation in Trypanosoma brucei, Proc Natl Acad Sci U S A, vol.95, pp.14687-92, 1998. ,
Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology, Mol Cell Proteomics, vol.12, pp.515-543, 2013. ,
Loopmediated isothermal amplification (LAMP) method for rapid detection of Trypanosoma brucei rhodesiense, PLoS Negl Trop Dis, vol.6, p.147, 2008. ,
, Biomarker of Treatment Efficacy in Human African Trypanosomiasis Journal of Clinical Microbiology, vol.51, pp.2379-2381, 2013.
Purification and characterisation of an extracellular released protease of Trypanosoma brucei, Parasitol. Res, vol.85, pp.424-428, 1999. ,
Correlation of high serum levels of tumor necrosis factor-alpha with disease severity in human African trypanosomiasis, Am J Trop Med Hyg. 1 9, vol.9, pp.539-582 ,
Inhibition of cytochrome P450 enzymes, Cytochrome P450: Structure, Mechanism, and Biochemistry, vol.3, pp.305-364, 1995. ,
Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis, PLoS Pathog, vol.6, p.1004165, 201410. ,
Enhancer mediated control of macrophage-specific arginase I expression, J Immunol, vol.172, pp.7565-73, 2004. ,
The molecular arms race between African trypanosomes and humans, Nature reviews Microbiology, vol.12, pp.575-584, 2014. ,
Physiological implications of sterol biosynthesis in yeast, Annu Rev Microbiol, vol.49, pp.95-116, 1995. ,
Modulation of innate immunity by African trypanosomes, Parasitology, vol.137, pp.2051-2063, 2010. ,
Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes, Science, vol.309, pp.469-472, 2005. ,
The trypanosome flagellar pocket collar and its ring forming protein-TbBILBO1, Cells, vol.5, p.9, 2016. ,
Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses, Eur. J. Immunol, vol.41, pp.3479-3494, 2011. ,
Targeting sterol metabolism for the development of antileishmanials, Trends in Parasitology, vol.31, pp.5-7, 2015. ,
Nifurtimoxeflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial, Lancet, vol.374, pp.56-64, 2009. ,
Dendritic cell development-History, advances, and open questions, Seminars in Immunology, vol.27, pp.388-396, 2015. ,
The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense, Am. J. Trop. Med. Hyg, vol.67, pp.684-690, 2002. ,
Novel primer sequences for a polymerase chain reactionbased detection of Trypanosoma brucei gambiense, Am. J. Trop. Med. Hyg, vol.67, pp.289-295, 2002. ,
Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans, Progress in Lipid Research, vol.52, pp.488-512, 2013. ,
Introduction to flow cytometry: principles, fluorochromes, instrument set-up, calibration, J Hematother, vol.2, pp.387-94, 1993. ,
Dendritic cells in a mature age, Nat Rev Immunol, vol.6, pp.476-83, 2006. ,
Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procylic cell trypanosomes, Proc. Natl. Acad. U.S.A, vol.106, pp.12694-12699, 2009. ,
Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa, Mol Biochem Parasitol, vol.126, pp.129-142, 2003. ,
Basal body movements as a mechanism for mitochondrial genome segregation in the trypanosome cell cycle, Nature, vol.352, pp.731-734, 1991. ,
Ultrastructural and biochemical alterations induced by 22,26-azasterol, a ?24(25)-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis, Antimicrobial Agents and Chemotherapy, vol.46, pp.487-499, 2002. ,
In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects, Antimicrobial Agents and Chemotherapy, vol.52, pp.4098-4114, 2008. ,
Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitor of squalene synthase, on Leishmania amazonensis, Experimental Parasitology, vol.111, pp.230-238, 2005. ,
The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development, J Parasitol Res, p.507874, 2012. ,
Molecular evolution of biomembranes: structural equivalents and phylogenetic precursors of sterols, Proc Natl Acad Sci U S A, vol.76, pp.847-851, 1979. ,
African trypanosomes: the genome and adaptations for immune evasion, Essays Biochem, vol.51, pp.47-62, 2011. ,
Trypanosome induced suppression of anti-parasite responses during experimental African trypanosomiasis, Eur J Immunol, vol.10, pp.971-974, 1980. ,
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin-4 and down-regulated by tumor necrosis factor ?, J Exp Med, vol.179, pp.1109-1127, 1994. ,
Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host, Science, vol.337, pp.463-466, 2012. ,
Resistance of human fungal pathogens to antifungal drugs, Curr Opin Microbiol, vol.5, pp.379-85, 2002. ,
Re(de)fining the dendritic cell lineage, nature immunology, vol.13, pp.1145-1154, 2012. ,
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives, Antimicrobial Agents and Chemotherapy, vol.51, pp.2123-2129, 2007. ,
Flagellar membranes are rich in raftforming phospholipids, Biology Open, vol.4, pp.1143-1153, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01301208
Innate recognition of Toxoplasma gondii in humans involves a mechanism distinct from that utilized by rodents, Semin Immunol, vol.27, pp.388-96, 2015. ,
Jannin JG Estimating and mapping the population at risk of sleeping sickness, PLoS Negl Trop Dis, vol.6, p.1859, 2012. ,
The mitochondrial genome of kinetoplastid protozoa: genomic organization, transcription, replication, and evolution, Annu Rev Microbiol, vol.41, pp.363-82, 1987. ,
Tumor immunity: a balancing act between T cell activation, macrophage activation and tumor-induced immune suppression, Cancer Immunol Immunother, vol.54, pp.1137-1179, 2005. ,
DOI : 10.1007/s00262-005-0703-4
Lipid metabolism in Trypanosoma brucei, Mol Biochem Parasitol, vol.172, pp.66-79, 2010. ,
In vitro and in vivo studies of the antiparasitic activity of sterol 14?-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi, Antimicrob Agents Chemother, vol.57, pp.4151-63, 2013. ,
Silencing of a putative inner arm dynein heavy chain results in flagellar immobility in Trypanosoma brucei, Mol Biochem Parasitol, vol.175, pp.68-75, 2011. ,
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution, J. Exp. Med, vol.137, pp.1142-1162, 1973. ,
A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis-associated immunopathology, J Immunol, vol.179, pp.4003-4014, 2007. ,
DOI : 10.4049/jimmunol.179.6.4003
URL : https://biblio.ugent.be/publication/8614907/file/8614908.pdf
mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function, Trends Immunol, vol.7, 2016. ,
Extracellular vesicles from Trypanosoma brucei mediate virulence factor transfer and cause host anemia, Cell, vol.164, pp.246-57, 2016. ,
DOI : 10.1016/j.cell.2015.11.051
URL : https://doi.org/10.1016/j.cell.2015.11.051
Fexinidazole-a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness, PLoS Negl Trop Dis, vol.4, p.923, 2010. ,
Cytochrome P-450dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation, J. Biol. Chem, vol.259, pp.13402-13412, 1984. ,
Flagellar membrane localization via association with lipid rafts, J Cell Sci, vol.122, pp.859-66, 2009. ,
DOI : 10.1242/jcs.037721
URL : http://jcs.biologists.org/content/122/6/859.full.pdf
Antiproliferative effects of ?24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies, Chemotherapy, vol.42, pp.294-307, 1996. ,
Inhibitors of ?24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii, Antimicrobial Agents and Chemotherapy, vol.41, pp.1428-1432, 1997. ,
Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania Mexicana, Molecular and Biochemical Parasitology, vol.125, pp.35-45, 2002. ,
In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi, Antimicrobial Agents and Chemotherapy, vol.48, pp.2379-2387, 2004. ,
Mechanism of Trypanosoma gambiense resistance to human serum, Nature, vol.501, pp.430-434, 2013. ,
DOI : 10.1038/nature12516
URL : https://hal.archives-ouvertes.fr/hal-02124025
Apolipoprotein L-I is the trypanosome lytic factor of human serum, Nature, vol.422, pp.83-87, 2003. ,
Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum, Proc. Natl Acad. Sci. USA, vol.104, pp.4118-4123, 2007. ,
A haptoglobin-haemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans, Science, vol.320, pp.677-681, 2008. ,
Alterations induced by the antifungal compounds ketoconazole and terbinafine in Leishmania, The Journal of Eukaryotic Microbiology, vol.42, pp.337-346, 1995. ,
Developmental cycles and biology of pathogenic trypanosomes, Br. Med. Bull, vol.41, pp.105-114, 1985. ,
Arginases in parasitic diseases, Trends Parasitol, vol.1, pp.9-12, 2003. ,
DOI : 10.1016/s1471-4922(02)00010-7
Sadenosyl-L-methionine inhibitors ?24-sterol methyltransferase and ?24(28)-sterol methylreductase as possible agents against Paracoccidioides brasiliensis, Antimicrobial Agents and Chemotherapy, vol.47, pp.2966-2970, 2003. ,
DOI : 10.1128/aac.47.9.2966-2970.2003
URL : https://aac.asm.org/content/47/9/2966.full.pdf
Ultrastructural alterations in Trypanosoma (Schizotrypanum) cruzi induced by ?24(25) sterol methyl transferase inhibitors and their combinations with ketoconazole, International Journal of Antimicrobial Agents, vol.7, pp.235-240, 1996. ,
DOI : 10.1016/s0924-8579(96)00325-1
Fatty acid uptake by bloodstream forms of Trypanosoma brucei and other species of the kinetoplastida, Mol Biochem Parasitol, vol.1, pp.177-186, 1980. ,
Sterols and other triterpenoids: source specificity and evolution of biosynthetic pathways, Org Geochem, vol.36, pp.139-159, 2005. ,
DOI : 10.1016/j.orggeochem.2004.06.013
Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway, Antimicrob Agents Chemother, vol.40, pp.253-259, 1996. ,
Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay, J. Biomed. Biotechnol, p.923193, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00493348
Microaerobic steroid biosynthesis and the molecular fossil record of Archean life, Proc. Natl. Acad. Sci. U. S. A, vol.108, pp.13409-13414, 2011. ,
Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters, J Biol Chem, vol.275, pp.40174-40183, 2000. ,
Regulatory T cells prevent control of experimental African trypanosomiasis, J Immunol, vol.180, pp.2514-2521, 2008. ,
A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei, Mol Biochem Parasitol, vol.99, pp.89-101, 1999. ,
Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma brucei, J Cell Sci, vol.95, pp.49-57, 1990. ,
Threedimensional models of wild-type and mutated forms of cytochrome P450 14alphasterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding, Antimicrob Agents Chemother, vol.48, pp.568-74, 2004. ,
A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense, Cell, vol.95, pp.839-846, 1998. ,
Sterol biosynthesis is required for heat resistance but not extracellular survival in Leishmania, PLoS Pathog, vol.10, p.1004427, 2014. ,
DOI : 10.1371/journal.ppat.1004427
URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004427&type=printable
Yeast cytochrome P-450 catalyzing lanosterol 14 alphademethylation. I. Purification and spectral properties, J. Biol. Chem, vol.259, pp.1655-1660, 1984. ,
Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta), J Immunol, vol.173, pp.586-93, 2004. ,
IL-17/Th17 in anti-fungal immunity: what's new?, Eur J Immunol, vol.39, pp.645-653, 2009. ,
DOI : 10.1002/eji.200839102
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation, Immunity, vol.45, pp.540-54, 2016. ,
Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei, J Lipid Res, vol.48, pp.665-673, 2007. ,
Differentiation of effector CD4T cell populations, Annu. Rev. Immunol, vol.28, pp.445-489, 2010. ,