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Acta Biotheoretica 56, 1-2 (2008) 75-86
Effect of the number of patches in a multi-patch SIRS model with fast migration on the basic reproduction rate
Etienne Kouokam ( ) 1, Pierre Auger ( ) 2, 3, 4, Hassan Hbid 5, Maurice Tchuente ( ) 1, 2, 3, 4
(2008)

We consider a two-patch epidemiological system where individuals can move from one patch to another, and local interactions between the individuals within a patch are governed by the classical SIRS model. When the time-scale associated with migration is much smaller than the time-scale associated with infection, aggregation methods can be used to simplify the initial complete model formulated as a system of ordinary differential equations. Analysis of the aggregated model then shows that the two-patch basic reproduction rate is smaller than the 1 patch one. We extend this result to a linear chain of P patches (P > 2). These results are illustrated by some examples for which numerical integration of the system of ordinary differential equations is performed. Simulations of an individual based model implemented with a multi-agent system are also carried out.
1 :  Laboratory MAT-IRD
University of Yaounde I
2 :  Institut Rhône-Alpin des systèmes complexes (IXXI)
INRIA – École Normale Supérieure - Lyon – Institut National des Sciences Appliquées (INSA) : - LYON – Université Claude Bernard - Lyon I – Ecole Normale Supérieure Lettres et Sciences Humaines – Université Joseph Fourier - Grenoble I – CNRS – Institut de recherche pour le développement [IRD]
3 :  Modélisation mathématique et informatique de systèmes complexes naturels, biologiques ou sociaux (GEODES)
Institut de recherche pour le développement [IRD]
4 :  MASAIE (INRIA Nancy - Grand Est / LMAM)
INRIA – Université Paul Verlaine - Metz – CNRS : UMR7122 – Université de Lorraine
5 :  Department of Mathematics [Marroco]
University of Menara
Sciences du Vivant/Médecine humaine et pathologie

Informatique/Complexité
SIRS model – two patch system – linear chain of patches – fast migration – aggregation of variables – basic reproduction rate – individual based model – multi agent simulations
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