Human/vector relationships during human African trypanosomiasis : Initial screening of immunogenic salivary proteins of Glossina species

Anne Poinsignon; Sylvie Cornelie; Franck Remoue; Pascal Grébaut; David Courtin; André Garcia; François Simondon

Human/vector relationships during human African trypanosomiasis : Initial screening of immunogenic salivary proteins of Glossina species

Anne Poinsignon ^{1, *} Sylvie Cornelie ¹ Franck Remoue ¹ Pascal Grébaut ² David Courtin ² André Garcia ³ François Simondon ¹

* Corresponding author

1 EPIPREV - Épidémiologie et prévention : environnement et efficacité des interventions

2 Trypanosomiases de l'homme, de l'animal et des plantes

3 Santé de la mère et de l'enfant en milieu tropical : épidémiologie génétique et périnatale

UPD5 - Université Paris Descartes - Paris 5 : UMRD216

Abstract : The morbidity and mortality of vector-borne diseases is closely linked to exposure of the human host to vectors. Qualitative and quantitative evaluation of individual exposure to arthropod bites by investigation of the specific immune response to vector saliva would make it possible to monitor individuals at risk of vectorial transmission of pathogens. The objective of this study was to evaluate and compare the antibody (IgG) response to saliva from uninfected Glossina species, vectors, or non-vectors of Trypanosoma brucei gambiense by detecting immunogenic proteins in humans residing in an area endemic for human African trypanosomiasis in the Democratic Republic of Congo. Our results suggest that the immunogenic profiles observed seemed specific to the Glossina species (vector or non-vector species) and to the infectious status of exposed individuals (infected or not infected). This preliminary work tends to support the feasibility of development of an epidemiologic tool based on this antibody response to salivary proteins.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Immunology

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Human/vector relationships during human African trypanosomiasis : Initial screening of immunogenic salivary proteins of Glossina species

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Human/vector relationships during human African trypanosomiasis : Initial screening of immunogenic salivary proteins of Glossina species

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