The derivation of leaf area index (LAI) from satellite optical data has been the subject of a large amount of work. In contrast, few papers have addressed the effective model inversion of high resolution satellite images for a complete series of data for the various crop species in a given region. The present study is focused on the assessment of a LAI model inversion approach applied to multitemporal optical data, over an agricultural region having various crop types with different crop calendars. Both the inversion approach and data sources are chosen because of their wide use. Crops in the study region (Barrax, Castilla-La Mancha, Spain) include: cereal, corn, alfalfa, sugar beet, onion, garlic, papaver. Some of the crop types (onion, garlic, papaver) have not been addressed in previous studies. We use in-situ measurement sets and literature values as a priori data in the PROSPECT+SAIL models to produce Look Up Tables (LUTs). Those LUTs are subsequently used to invert Landsat-TM and Landsat-ETM+ image series (12 dates from March to September 2003). The Look Up Tables are adapted to different crop types, identified on the images by ground survey and by Landsat classification. The retrieved LAI values are compared to in-situ measurements available from the campaign conducted in mid July-2003. Very good agreement (a high linear correlation) is obtained for LAI values from 0.1 to 6.0. LAI maps are then produced for each of the 12 dates. The LAI temporal variation shows consistency with the crop phenological stages. The inversion method is favourably compared to a method relying on the empirical relationship between LAI and NDVI from Landsat data. This offers perspectives for future optical satellite data that will ensure high resolution and high temporal frequency.