A new phthalide derivative from Peperomia nivalis

Pedro Vásquez-Ocmín 1 Mohamed Haddad 2 Alice Gadea 2 Valérie Jullian 2 Denis Castillo 1 Lucie Paloque 3 Juan Cerapio 1 Geneviève Bourdy 2 Michel Sauvain 2
1 Laboratorio de Enfermedades Infecciosas, Laboratorios de Investigacion y Desarrollo
2 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
3 LCC - Laboratoire de chimie de coordination
Abstract : One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (1 H and 13 C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1–3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC 50 8.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.
Keywords : Peperomia nivalis Helicobacter pylori Plasmodium NMR phthalide secondary metabolites
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Pedro Vásquez-Ocmín, Mohamed Haddad, Alice Gadea, Valérie Jullian, Denis Castillo, et al.. A new phthalide derivative from Peperomia nivalis. Natural Product Research, Taylor & Francis, 2017, 31 (2), pp.138-142. ⟨10.1080/14786419.2016.1219857⟩. ⟨ird-01381569⟩

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