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Spatio-temporal dynamics of asymptomatic malaria : bridging the gap between annual malaria resurgences in a Sahelian environment
Drissa Coulibaly
1
Mark Travassos
1
Youssouf Tolo
1
Matthew Laurens
1
Abdoulaye Koné
2
Karim Traore
3
Mody Sissoko
4
Amadou Niangaly
1
Issa Diarra
1
Modibo Daou
Boureima Guindo
Stanislas Rebaudet
5, 6
Bourema Kouriba
7
Nadine Dessay
8
Renaud Piarroux
6
Christopher Plowe
Ogobara Doumbo
9, 10
Mahamadou Thera
2
Jean Gaudart
4, 10
Issa Diarra 1
Author
Modibo Daou
Author
Boureima Guindo
Author
Stanislas Rebaudet 5, 6
Mail :
Author
Bourema Kouriba 7
Author
Nadine Dessay 8
Mail :
Author IdHAL : nadine-dessay ResearcherId : http://www.researcherid.com/rid/J-9856-2016 ORCID : https://orcid.org/0000-0003-0526-3531
Renaud Piarroux 6
Author
Christopher V Plowe
Author
Ogobara Doumbo 9, 10
Author
Mahamadou Ali Thera 2
Author
Jean Gaudart 4, 10
Mail :
Author IdHAL : jean-gaudart ISNI : http://isni.org/isni/0000000359177188 ORCID : https://orcid.org/0000-0001-9006-5729 ResearcherId : http://www.researcherid.com/rid/D-9071-2013
1
Département d'Epidémiologie des Affections parasitaires, Malaria Research and training center Université de Bamako, Mali (Faculté de Médecine et d'Odonto-stomatologie BP 1805 Point G, Bamako - Mali)
- Université de Bamako (BP E.2528 Bamako - Mali)
2
DEAP - Département d'épidémiologie des affections parasitaires (BP1805 Bamako - Mali)
- Université de Bamako (BP E.2528 Bamako - Mali)
- Malaria Research and Training Center (MRTC) (France)
- Facultés de Médecine, de Pharmacie et d'Odonto-Stomatologie (France)
- CNRS - Centre National de la Recherche Scientifique : UMI3189 (France)
3
IMETI - Institut des Maladies Emergentes et des Thérapies Innovantes (France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DSV/IMETI (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
4
AMU - Aix Marseille Université (Aix-Marseille Université
Jardins du Pharo
58 Boulevard Charles Livon
13284 Marseille cedex 7 - France)
5
APHM - Assistance Publique - Hôpitaux de Marseille (Direction générale AP-HM
80, rue Brochier
13 354 Marseille Cedex 5 - France)
6
iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique (56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1136 (101, rue de Tolbiac, 75013 Paris - France)
8
UMR 228 Espace-Dev, Espace pour le développement (IRD - Maison de la Télédétection - 500 rue Jean-François Breton - 34093 Montpellier - France)
- UA - Université des Antilles (Université des Antilles | Fouillole - BP 250 - 97157 Pointe-à-Pitre - France)
- UG - Université de Guyane (Campus de Troubiran - BP 20792- 97337 Cayenne Cedex - Guyane - French Guiana)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
- UR - Université de La Réunion (15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9 - Réunion)
- AU - Avignon Université (74 rue Louis Pasteur - 84 029 Avignon cedex 1 - France)
- UPVD - Université de Perpignan Via Domitia (52 avenue Paul Alduy - 66860 Perpignan Cedex 9 - France)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
9
Malaria Research and Training Centre (BP 1805, Bamako - Mali)
- Université de Bamako (BP E.2528 Bamako - Mali)
- Faculty of Medicine, Pharmacy (France)
10
SESSTIM - U912 INSERM - Aix Marseille Univ - IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (Faculté de Médecine - Site Timone - 27 Bd Jean Moulin 13385 – Marseille Cedex 05 - France)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- AMU - Aix Marseille Université (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U912 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : These authors contributed equally to this work. Abstract. In areas of seasonal malaria transmission, the incidence rate of malaria infection is presumed to be near zero at the end of the dry season. Asymptomatic individuals may constitute a major parasite reservoir during this time. We conducted a longitudinal analysis of the spatio-temporal distribution of clinical malaria and asymptomatic parasitemia over time in a Malian town to highlight these malaria transmission dynamics. For a cohort of 300 rural children followed over 2009–2014, periodicity and phase shift between malaria and rainfall were determined by spectral analysis. Spatial risk clusters of clinical episodes or carriage were identified. A nested-case-control study was conducted to assess the parasite carriage factors. Malaria infection persisted over the entire year with seasonal peaks. High transmission periods began 2–3 months after the rains began. A cluster with a low risk of clinical malaria in the town center persisted in high and low transmission periods. Throughout 2009–2014, cluster locations did not vary from year to year. Asymptomatic and gametocyte carriage were persistent, even during low transmission periods. For high transmission periods, the ratio of asymptomatic to clinical cases was approximately 0.5, but was five times higher during low transmission periods. Clinical episodes at previous high transmission periods were a protective factor for asymptomatic carriage, but carrying parasites without symptoms at a previous high transmission period was a risk factor for asymptomatic carriage. Stable malaria transmission was associated with sustained asymptomatic carriage during dry seasons. Control strategies should target persistent low-level parasitemia clusters to interrupt transmission.
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Journal articles
Domain :
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https://hal.ird.fr/ird-01630569
Contributor : Nadine Dessay <>
Submitted on : Tuesday, November 7, 2017 - 5:48:21 PM
Last modification on : Tuesday, March 24, 2020 - 1:36:11 PM
Document(s) archivé(s) le : Thursday, February 8, 2018 - 3:04:03 PM
Contributor : Nadine Dessay <>
Submitted on : Tuesday, November 7, 2017 - 5:48:21 PM
Last modification on : Tuesday, March 24, 2020 - 1:36:11 PM
Document(s) archivé(s) le : Thursday, February 8, 2018 - 3:04:03 PM
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Identifiers
- HAL Id : ird-01630569, version 1
- DOI : 10.4269/ajtmh.17-0074
- IRD : fdi:010072015
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IRD | CNRS | UPMC | CEA | UNIV-AMU | IPLESP | UNIV-PARIS-SACLAY | ESPACE-DEV | AGROPOLIS | GUYANE | MIPS | UNIV-MONTPELLIER | JACOB | CEA-DRF | UNIV-AG | CEA-UPSAY | U1252 | SORBONNE-UNIVERSITE | SU-MEDECINE | UNIV-AVIGNON | UNIV-PERP
Citation
Drissa Coulibaly, Mark Travassos, Youssouf Tolo, Matthew Laurens, Abdoulaye Koné, et al.. Spatio-temporal dynamics of asymptomatic malaria : bridging the gap between annual malaria resurgences in a Sahelian environment. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2017, 20 p. ⟨10.4269/ajtmh.17-0074⟩. ⟨ird-01630569⟩
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