Skip to Main content Skip to Navigation
New interface
Journal articles

cDNA sequencing and expression analysis of Dicentrarchus labrax heme oxygenase-1.

Abstract : The liver cDNA encoding heme oxygenase--1 (HO-1) was sequenced from European sea bass (Dicentrarchus labrax) (accession number no. EF139130). The HO-1 cDNA was 1250 bp in nucleotide length and the open reading frame encoded 277 amino acid residues. The deduced amino acid sequence of the European sea bass had 75% and 50% identity with the amino acid sequences of tetraodontiformes (Tetraodon nigroviridis and Takifugu rubripes) and human HO-1 proteins, respectively. A short hydrophobic transmembrane domain at the C--terminal region was found, and four histidine residues were highly conserved, including human his25 that is essential for HO catalytic activity. RT-PCR of mRNA from eight different European sea bass tissues revealed that, in a homeostatis state, the heme oxygenase--1 was abundant in the spleen and liver but not in the brain.
Document type :
Journal articles
Complete list of metadata
Contributor : NATHALIE PREVOT D'ALVISE Connect in order to contact the contributor
Submitted on : Saturday, June 30, 2018 - 10:03:49 AM
Last modification on : Friday, April 1, 2022 - 3:18:32 PM


  • HAL Id : ird-01826905, version 1
  • PUBMED : 19116084


Nathalie Prévot d'Alvise, S. Pierre, E Gouze, J Gouze, J Aubert, et al.. cDNA sequencing and expression analysis of Dicentrarchus labrax heme oxygenase-1.. Cellular and Molecular Biology, 2008, pp.OL1046-54. ⟨ird-01826905⟩



Record views