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Favipiravir inhibits Mayaro virus infection in mice

Abstract : Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectrum antiviral drug, has recently been shown to exert anti-MAYV activity in vitro. In the present study, the potential of Favipiravir to inhibit MAYV replication in an in vivo model was evaluated. Immunocompetent mice were orally administrated 300 mg/kg/dose of Favipiravir at pre-, concurrent-, or post-MAYV infection. The results showed a significant reduction in infectious viral particles and viral RNA transcripts in the tissues and blood of the pre- and concurrently treated infected mice. A significant reduction in the presence of both viral RNA transcript and infectious viral particles in the tissue and blood of pre- and concurrently treated infected mice was observed. By contrast, Favipiravir treatment post-MAYV infection did not result in a reduction in viral replication. Interestingly, Favipiravir strongly decreased the blood levels of the liver disease markers aspartate- and alanine aminotransferase in the pre- and concurrently treated MAYV-infected mice. Taken together, these results suggest that Favipiravir is a potent antiviral drug when administered in a timely manner.
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https://hal.ird.fr/ird-03610133
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Submitted on : Wednesday, March 16, 2022 - 10:45:57 AM
Last modification on : Monday, September 5, 2022 - 2:44:06 PM
Long-term archiving on: : Friday, June 17, 2022 - 6:44:50 PM

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Michèle Bengue, Ai-Rada Pintong, Florian Liégeois, Antoine Nougairède, Rodolphe Hamel, et al.. Favipiravir inhibits Mayaro virus infection in mice. Viruses, 2021, 13 (11), pp.2213. ⟨10.3390/v13112213⟩. ⟨ird-03610133⟩

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